Unlock the Secret to Timeless Skin: The Science Behind Areoveda's Anti-Aging Test!
Hey there, skincare enthusiasts! We know you've been on a quest to defy the aging process and keep your skin looking youthful and radiant. Well, who isn't? We all want our skin to defy the hands of time, and that's where anti-aging products come into play. But how do you know if those potions and lotions are really working their magic? At Areoveda, we take the guesswork out of the equation by subjecting our formulations to a rigorous anti-aging test. Get ready to uncover how our products turn back the clock on your skin!
What Do We Mean By Aging Skin?
Aging is an inevitable part of life, and our skin is no exception to this natural process. As we grow older, our skin undergoes significant changes, leading to visible signs of aging like wrinkles and sagging.
Reason?
You can blame the decline in the number of dermal fibroblasts cells!1
Why Are Dermal Fibroblasts Important To Our Skin?1
So, what are these cells that you have never really heard of and why are they crucial to our anti-aging quest?
Dermal fibroblasts are the predominant cells within the dermal extracellular matrix, responsible for maintaining skin health and vitality. They are the architects of youthful skin, producing essential proteins such as collagen, elastin, laminin, and fibronectin. These proteins give our skin its elasticity, firmness, and the ability to repair itself.2
But as we age, the number and activity of fibroblasts diminish, compromising our skin's regenerative abilities. This decline is a primary driver behind the visible signs of aging. To address this, we turn to dermal fibroblasts as a vital tool in our skincare research. Unlike testing on living organisms (in vivo), using dermal fibroblast cell lines allows us to mimic how our products work on your skin with remarkable accuracy.3
The Anti-Aging Test Journey: Days 1 to 3 1, 2, 3
Here's a quick rundown of what happens during our three-day anti-aging test:
Day 1:
Step 1: Aging the Cells and application of test product
Our journey to unlock the secrets of anti-aging begins with a process known as 'aging' the dermal fibroblasts. We expose these cells to hydrogen peroxide (H₂O₂), a naturally occurring compound produced by dermal fibroblasts during various physiological processes. This exposure induces oxidative stress, simulating the oxidative environment of aging skin. The result? These cells prematurely enter a state of senescence, losing their ability to produce collagen and contributing to extracellular matrix breakdown.
Step 2:
We introduce the test product (AreoVeda Product) along with a cell media containing essential nutrients and compounds that can control the physicochemical properties of the dermal fibroblasts and incubate for 24 hrs. This dynamic combination triggers the following remarkable transformation:
- Collagen and elastin production kick-starts.
- Catalase, an enzyme that breaks down H₂O₂, regains its function.
- Levels of reactive oxygen species (ROS) and free radicals decrease.
- Collagenase, an enzyme that degrades collagen, diminishes.
- Tissue inhibitors of metalloproteinases (TIMP) levels increase, inhibiting collagenase function.
- Silent genes for actin protein expression are activated, aiding in regaining contractile properties and elasticity.
Day 2:
Step 1: Tracking the mRNA Levels
We're not done yet! We closely monitor the temporary copies of DNA, called mRNA, which instruct cells to produce specific proteins like collagen and elastin. Using advanced RT-PCR technology, we compare the mRNA expression levels between cells treated with our product and those that are untreated. These results give us a clear picture of how our product is working its magic on these cells.
At AreoVeda, we ensure that our products not only meet but exceed the highest standards of anti-aging efficacy. Our rigorous testing guarantees that your skin remains youthful and vibrant.
AreoVeda’s Skin Clarifying Serum undergoes the anti-aging test.
The Final Verdict: Youthful Skin!
Now, for the moment of truth! To be considered an anti-aging product, our dermal fibroblast cell lines which are treated with our test product should show higher mRNA expression levels for collagen and elastin compared to positive control cells which are exposed to hydrogen peroxide & growth media for 24 hours. And guess what? At Areoveda, all our tested products pass with flying colors!
So, there you have it - our secret sauce to combat aging and keep your skin looking youthful and fabulous. Remember, your skin deserves the best, and at Areoveda, we're here to deliver just that. Stay tuned for more skincare secrets and tips from us. Until then, keep glowing!
References
+
